Interferon regulatory factor 3 is a potential biomarker to predict the process of atherosclerosis

Cardiovascular diseases is one of the major public health and medical concerns globally. Atherosclerosis a condition where plaque build-up narrows blood vessels, ultimately preventing sufficient flow to heart. In current research, role played by human innate immune system in development atherosclerosis topic interest. Although specific relations require further studies, macrophages have been identified play key progression due their ability mediate inflammation. Nevertheless, mechanism that how cause inflammatory responses atherosclerotic process what risk factor can describe inflammation clinic still remains unclear. This paper reviews trigger relationships atherosclerosis. this study, Interferon Regulatory Factor 3 (IRF3) its-related cytokine interleukin 1β was found be upregulated patients with acute coronary disease. Afterwards, over-expressed IRF3 level its RNA transcription confirmed ApoE -/- mice. Our results indicated up-regulated during process, which might potential biomarker disease clinic.